Can I Take CBD Oil With Prednisone?

Can I Take CBD Oil With Prednisone?

Can I Take CBD Oil With Prednisone?

Prednisone is an anti-inflammatory drug that was popular before CBD took center stage. The reduction in the prescription of prednisone is due to a range of side effects associated with it. These side effects have left patients with no choice but to seek alternative treatments. CBD has been earning rave reviews from patients and doctors because of its undeniable medical benefits. It has proven to be effective in the treatment of inflammation. Besides, it is safer than prednisone because of its relatively low-risk side effect. However, many people are asking, “can I use CBD oil with prednisone?”

People who ask this question wants to be sure that CBD will not interact with prednisone to make matters worse. Some people are also interested to know whether combining the two medications can form a letter anti-inflammatory combination. CBD is a chemical compound. Therefore, it interacts with other drugs. Is prednisone one of those drugs? You will find the answer and other useful information as you read on. In the end, you will be able to answer the question: “Can I take CBD oil with prednisone?”

Can I Take CBD Oil With Prednisone? Why Inflammation?

Before we proceed to answer the question, “can I take CBD oil with prednisone?”, let us examine what causes inflammation. Inflammation is an integral part of the body’s natural routine for fighting infections, healing wounds, and destroying damaged cells. Nonetheless, if things go wrong, it can cause specific ailments, including rheumatoid arthritis and heart disease. Doctors often prescribe corticosteroid medications such as prednisone to combat the effects of inflammation. Inflammation can be dangerous. To prevent it from wreaking havoc, there are supplements, anti-inflammatory diets, and lifestyle recommendations to help keep it in check.

Nonetheless, the body cannot do without inflammation. It plays a critical role in helping the body heal itself. It is the response of the immune system that eliminates foreign invaders and repairs damaged tissues. So, without inflammation, the body is in trouble. It will not be able to heal from infections and wounds. Acute inflammation is a good sign because it is an immediate immune response. When you are injured, the damaged tissues release proteins called cytokines. These proteins signal the body to release prostaglandins (a hormone).

Alongside prostaglandins, the body also releases neutrophils. Neutrophils are white blood cells that repair damaged tissues. Due to the immune response, blood vessels will enlarge to make fluids and proteins reach the site of the injury. The inflammation process involving immune response is responsible for redness, pain, and swelling when you have a wound. As the process continues, you may have a fever, and fluids can collect at the damaged tissue’s site. Can I take CBD oil with prednisone? Keep reading.

Can I Take CBD Oil With Prednisone? Prednisone and Inflammation

Prednisone belongs to a group of drugs called corticosteroids. These are synthetic steroids, but they are not the same as the ones athletes use to build muscles. This category of medications is prescribed to fight inflammation. These drugs are useful, primarily when the inflammation is associated with chronic autoimmune disorders. They are beneficial in helping to deal with diseases that create a burning sensation. Like lupus or rheumatoid arthritis, autoimmune disorders arise from the attack of healthy tissues by the immune system. Other diseases in this category include skin allergies and multiple sclerosis.

The immune system can mistake healthy tissues for bacteria or viruses, and this is also the basics of cancerous growths. The body’s first response to a disorder or injury is inflammation to begin the healing process. However, inflammations often leave people in more pain than the ailments themselves. Prednisone acts as an immunosuppressant to provide relief for people suffering from inflammatory diseases.

Corticosteroids help to rescue the body from the malady of the immune system by mimicking the actions of cortisol. Cortisol is a hormone produced by the adrenal glands, often as a response to stress. This hormone is responsible for the regulation of body processes like immune response and metabolism. Corticosteroids like prednisone mimic the actions of cortisol to dampen the actions of the immune system. This reduction in immune response mitigates damages to the tissues. Can I take CBD oil with prednisone? Not yet.

Can I Take CBD Oil With Prednisone? CBD and Inflammation

Can I Take CBD Oil With Prednisone?

Cannabidiol is one of the numerous phytocannabinoids extracted from the cannabis plant. It has been in use for thousands of years because of its numerous health benefits. After several experiments, experts are now able to extract it without the intoxicating properties. Note that CBD does not have intoxicating effects. It is THC, another compound extracted from the cannabis plant that is a psychoactive substance. Hence, the lesser the content of THC in CBD, the lesser the intoxicating effect. In the US, CBD products must not have more than 0.03% THC content.

Research has shown that CBD is effective against inflammation. In a review of studies in 2009 about CBD’s effectiveness, the efficacy of the substance was confirmed. The researchers concluded that CBD has anti-inflammatory properties. CBD helps against inflammation because it suppresses immune responses, just like corticosteroids. Nonetheless, CBD has fewer side effects, unlike corticosteroids, which makes it the preferred choice.

More so, anecdotal accounts also claim that CBD is beneficial to chronic inflammatory patients. Many people have reported that CBD products have helped them to reduce chronic joint pain and inflammation. Does that answer the question: “Can I take CBD oil with prednisone?” Far from it!

Can I Take CBD Oil With Prednisone Without Prescription?

The consumption and legalization of CBD are on the rise. Nonetheless, research about it is still in its infancy. Therefore, you should not consume CBD products without medical consultation. Besides, it is not a healthy and safe practice to experiment with medications without a doctor’s prescription. Regarding the combination of CBD oil and prednisone, you should seek professional counsel before you go ahead with it. You may be exposing yourself to unknown side effects by using drugs without a doctor’s recommendation.

Indeed, both CBD oil and prednisone have anti-inflammatory properties. Naturally, you may be tempted to combine them to harness the healing power of both drugs. However, drug interactions are not as simple as adding one to one to get two. CBD oil helps against inflammation with lower side effects, unlike prednisone. You may feel that CBD oil will mask the side effects of prednisone when you use them together.

Nonetheless, you are still assuming, and assumptions can be dangerous. Your health is far too sensitive for careless experimentation. Can I take CBD oil with prednisone? It is a needless experiment.

More so, the fact that you know people who combine these two medications does not mean you should follow suit. Body systems differ in various ways. Someone can take a drug or combine drugs with improving his or her medical condition. The person can even report feeling better after the trial and error. However, you may regret it when you try it. So, it is always safe to talk to your doctor. Answering the question, “can I take CBD oil with prednisone?” is not straightforward. Nonetheless, it will become more apparent as we proceed.

Can I Take CBD Oil With Prednisone? Drug Metabolism Basics

Can I Take CBD Oil With Prednisone?

To help you understand how drugs affect your body, let us explore the basics. You need to understand drug metabolism to answer the question: “Can I take CBD oil with prednisone?” CBD can affect the actions of the enzymes responsible for breaking down drugs in your body. Enzymes are mostly protein chains that are chemically active to speed up reactions. Cytochrome P450 enzymes (CYP450) are the enzymes that primarily break down prescription medications in the body.

The human body has over 50,000 different CYP450 enzymes, and they are present in tissues all over the body. These enzymes metabolize more than 60% of prescription medications. A drug travels to your stomach after swallowing it. In most cases, the medication leaves the stomach without chemical reactions until they arrive at the small intestine. When they get there, enzymes will start breaking them down to aid their absorption into the bloodstream. Can I take CBD oil with prednisone? You will know very soon.

The medication travels to the liver through the hepatic portal vein. Enzymes in the liver break down the medication further before it enters the bloodstream. Once in the bloodstream, the drug is circulated the other parts of the body. After the circulation through the rest of the body, the medication passes through the liver. Can I take CBD oil with prednisone? You will find out soon.

Can I Take CBD Oil With Prednisone? The Interaction

It is not every medication you take that makes it to the systemic bloodstream. Some are not absorbed by the digestive system and never leaves the liver because CYP450 enzymes make them chemically inactive. This loss of active ingredients is called the first-pass effect. The percentage of the drug that makes it to the bloodstream is known as the bio availability of a drug. A higher bio availability increases the chances of the medication’s medication. Prednisone has a 70% bio availability. So, Can I take CBD oil with prednisone?

You need to understand CBD’s interaction with prednisone to answer the question:  “Can I take CBD oil with prednisone?” CBD has a profound impact on prednisone first-pass effect. CYP3A4 is the CYP450 enzyme responsible for the metabolism of prednisone. According to research, CBD strongly inhibits the activity of this enzyme. It is not clear how it does this. Nonetheless, it is hypothesized that it binds to the active sites of the enzyme, thereby neutralizing it.

CBD does not allow the enzymes to bind to a medication, which makes them chemically inactive. Unfortunately, this effect does not wear off over time. The enzyme remains this way permanently. Nonetheless, if you wait for your body to create a new batch of enzymes, things can go back to normal. It is not clear how long it takes for the body to create this new set of enzymes. Can I take CBD oil with prednisone? You know better now.

Can I Take CBD Oil With Prednisone Without Side Effects?

Asking “can I take CBD oil with prednisone?” is like asking if you can consume poison but not get hurt. CBD’s action on CYP3A4 in your liver can increase the dose of prednisone in your bloodstream. This excess dosage will multiply the side effects of prednisone. Hence, you may experience dizziness, blurred vision, aggression, agitation, and irritability. In some cases, you can also experience shortness of breath, confusion, fatigue, and decreased ability to fight infections. So, can I take CBD oil with prednisone? It is too risky.

Both CBD and prednisone have anti-inflammatory properties. Nonetheless, they do not go about their activities in the same way. CBD interacts with the endocannabinoid system, while prednisone reduces inflammation by directly attacking the immune system. CBD leverages endocannabinoid’s role in immunoregulation to reduce inflammation. Mixing both medications can produce side effects you will prefer to avoid. So, can I take CBD oil with prednisone? It is not advisable.

Studies on the effect of combining them are few. Nevertheless, CBD acts like a drug called ketoconazole. This medication inhibits the activities of CYP450 enzymes. Patients using ketoconazole are given smaller doses of prednisone. Can I take CBD oil with prednisone? If I were you, I would not do it. Anyway, in your best interest, do not experiment with drugs. Your doctor’s treatment plan is always your best bet, and it is better to stick with it.

Can I Take CBD Oil With Prednisone? Final Thoughts

The fact that a practice is widespread does not mean it is safe. Do not join the bandwagon, who feels they can combine drugs at will. Can I take CBD oil with prednisone? If I were in your shoes, I would speak to my doctor first. CBD helps against inflammation with fewer side effects. Why not just stick with it? There is no point in retaking prednisone when CBD can provide the relief you need. So, it is of no use asking: “Can I take CBD oil with prednisone?”

 

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References

Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry, 1(7), 1333–1349. https://doi.org/10.4155/fmc.09.93

Ferry JJ, Horvath AM, Bekersky I, Heath EC, Ryan CF, Colburn WA. The relative and absolute bioavailability of prednisone and prednisolone after separating oral and intravenous doses. J Clin Pharmacol. 1988;28(1):81-87. DOI:10.1002/j.1552-4604.1988.tb03105.x

WebMD. Drugs & Medications. Retrieved June 24, 2020, from https://www.webmd.com/drugs/2/drug-11593/ketoconazole-oral/details

 

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