CBD Tolerance, What is it?

CBD Tolerance

CBD Tolerance

You might be one of those people that started using CBD with enthusiasm but now disappointed. You probably used it, but it did not improve your health conditions. However, before you end this “relationship” with CBD, you need to consider some factors. Could it be that your body’s CBD tolerance level is on the rise? Have you been getting your products from top-quality sources? These and many more are the questions you need to answer before giving up on CBD. For some people, they initially got good results from using CBD, but it tailed off later. This pattern points to CBD tolerance.

CBD is a chemical compound extracted from the cannabis plant, just like THC. However, it offers medicinal benefits without getting you “high.” It is a crucial ingredient in many drugs, skin care products, and edibles. To think that the whole hype around CBD is a scam will be harsh and unfair. CBD has been earning rave reviews because of its effectiveness in treating various diseases like chronic pain and seizures. Besides, this famed curative effect is not based on assumptions but backed but by scientific evidence. In this article, we will consider various factors that can make CBD less effective when you use it.

CBD Tolerance: Is it Possible?

Indeed, research has shown that prolonged use of tetrahydrocannabinol (THC) can lead to THC tolerance. This means that you will need more of the substance to feel its effects. However, CBD tolerance works in the opposite direction. Scientific reviews and studies have demonstrated that the use of CBD oil will not lead to CBD tolerance. Nonetheless, long-term use may produce reverse tolerance. “Reverse tolerance” implies that you will need less of a drug to experience its effects with prolonged use. Therefore, people who use CBD may end up needing lower doses to find relief from diseases and their symptoms.

The cannabis plant contains more than 100 phytocannabinoids, and CBD is just one of them. The human body produces endocannabinoids, which are chemically similar to phytocannabinoids. Both phytocannabinoids and endocannabinoids interact with the body’s endocannabinoid system (ECS). The general idea is that CBD indirectly activates cannabinoid receptors in this system without binding to them. This action increases the number of endocannabinoids naturally produced by the body as time goes on. Meanwhile, as the body has more endocannabinoids, the higher the chances of CBD tolerance. Hence, CBD tolerance is plausible.

Note that research on CBD oil and reverse tolerance is not yet fully established. What is available for now is anecdotal evidence and personal experimentation.  Although CBD oil will not intoxicate you, it is in your best interest to start with a lower dose. This approach will enable you to test out our CBD tolerance. You will be able to track and measure your best dosage by steadily increasing your intake quantity. It may take you a few weeks or months, but it is worth it. You will be able to detect when you acquire CBD tolerance and reduce the dose.

CBD Tolerance: Possible Reasons

If you have never enjoyed the medicinal benefits of CBD oil use or it stopped, check the following factors:

Your Source of Supply

CBD Tolerance

If your CBD is not from a reputable source, you are at risk of buying inferior quality products. As the substance’s popularity increases, the higher the chances of the proliferation of fake products. In fact, CBD is rampant in recent times. From over-the-counter shops to online companies, CBD products are everywhere. Some companies will even offer you a free sample where all you will need to pay is the shipping cost. However, you should not be too eager to buy CBD oil from any source. Bid your time to confirm the credibility of any seller before investing in the product.

The Food and Drug Administration (FDA) is yet to approve non-prescription CBD products. Therefore, many corrupt organizations and individuals are taking full advantage of this to offer low-quality products. A group of researchers led by Bon-Miller analyzed 84 CBD products to evaluate their authenticity in 2017. Unfortunately, only 31 percent of the products had the quantity of CBD that was advertised. The issue of incorrect labeling is a serious problem ravaging the industry. So, you need to tread carefully to avoid investing in inferior quality products.

To ensure that you get the best quality CBD products, check for evidence of third-party lab tests. These tests reveal the exact amount of CBD present in a product. You should also read customer reviews of the product. Find out about what other people are saying about the product’s effectiveness, customer service, and brand’s delivery time. Also, you should pick from a list of reputable companies to avoid regrets in the future. Many CBD users were able to find a credible supplier after several trials. Do not stick to a seller whose product is not satisfactory.

Inadequate Consolidation

CBD may not be working for you because you are yet to build it up in your system. It can be tricky to find the right dosage. Individual differences play a massive role in determining what works best for each person. Every person has unique biology, and this often leads to different reactions. Therefore, it is in your best interest to start and progress gradually. CBD is a safe substance that does not produce addiction. Nonetheless, find the right dosage by increasing the amount while noticing your body reactions.

Note the quantity that results in the desired effect and stick with it. Some people were able to steadily build CBD in their system by taking a daily dosage. This method can work for you. It can stimulate your endocannabinoid system, thereby increasing its reaction to cannabinoids like CBD. Some folks also adopt a micro dosing technique to know their ideal dosage. This method involves adjusting the amount as needed over time. You can leverage a journal to monitor the results of each dosage.

Keep track of the quantity you take and how you feel. Notice the changes in the symptoms and record them for evaluation. With the aid of this info, you will eventually find the right dose for you. Note that just like any other chemical substance, CBD tolerance is possible. So, monitor your intake to note when you start or stop feeling the effects of the substance.

You Are In a Hurry

Many people have been in the same position of wondering if their investment in CBD is worth it. Do not conclude so fast. It is not everyone that used this substance that got instant results. In fact, immediate impacts are fewer. So do not go on social media yet to express your grievance and disappointment. You may have to apologize later. Many people were only able to enjoy the benefits of CBD after several weeks or even months. Of course, you would have preferred to get an instant result, but it is not often like that.

More so, you are getting it wrong if you think exploring the effects of CBD is like trying Tylenol. In that situation, you can just take some dose and quit because you do not see changes. Nevertheless, in the case of CBD, a few days or weeks is not enough to call it a day. Using CBD to treat any illness requires a certain level of commitment. Those who are not ready to be patient cannot enjoy the benefits of leveraging this substance.

In most cases, CBD is not suitable for offering instant relief. For example, doctors do not usually prescribe it for acute migraine or cluster headaches. However, it is fantastic for chronic cases. So, if you need a cure that can produce an instant result, you may need to explore another product.

You Need a Different Form

CBD products are popping up everywhere, and this gives you different options. It is easy to find products such as CBD coffee, lube, and bath salts out there. You can also find tinctures, vape oils, topical creams, gummies, and capsules or suppositories. Hence, you can explore different products until you find what works best for you.

Bio availability is a critical factor when it comes to the effectiveness of a substance. Try another delivery system if you are no getting the desired effect from one. If CBD does not get into your bloodstream appropriately, you cannot experience its benefits. The current delivery system may not offer the best bio availability. For example, gummies have to go through your digestive tract before absorption. So, the quantity that gets into your bloodstream, in the end, may not be enough.

A tincture is likely to work faster because you will take it sublingual (under your tongue). Hence, it offers better bio availability in comparison to edibles. The type of relief you want also determines the method you need. For example, if you want relief for panic attacks, a topical balm is not a suitable option. However, a topical balm will work effectively for sore muscles. So, the problem may not be CBD tolerance, but the delivery system you use.

CBD is Just Not for You

CBD Tolerance

It is hard to admit it because of the popularity of CBD, but it may not be for you. You should not conclude very fast, but you may get to that point eventually. CBD tolerance is real. Nonetheless, it may not be the reason you are not enjoying its medicinal effects. You may just need to try a different product. The factors that can make CBD unsuitable for you include biochemistry, metabolism, and genetics.

Your endocannabinoid system may not be interacting with the substance correcting. Research has proven that some people’s systems may react in a way that negates the impact of CBD. For example, a clinical psychiatry professor pointed out that genetic mutation can increase CBD tolerance. Such people’s body naturally produces excessive endocannabinoids. Hence, CBD will not be able to have the desired impact on such people.

For example, you may be battling anxiety. If you have that mutation, CBD will not be able to lower your anxiety level because of the extra endocannabinoids. So, always speak to your doctor to find the best option for you. Do not let anyone pressure you to stick with CBD if it is not working for you for months. Besides, no treatment has the same effect on everyone.

CBD Tolerance: How to Prevent It?

If you are having problems with CBD tolerance, you can mitigate it by trying the following approaches:

Increase Your Dose

It is possible that you need a higher dose to overcome CBD tolerance. Note that taking higher doses has side effects like drowsiness. So, it is always better to start gradually. Nonetheless, it comes at a price. You will have to spend more money as you increase the dosage. Medical experts often recommend that you build up CBD steadily in your system. If you do not see the previous effects, increasing the dosage is a good option.

Stop For a While

You may need to take a break to win the battle against CBD tolerance. Stopping CBD use for a short period can give your receptors a “reset” to become more sensitive. This approach can help your system refresh, get rid of CBD tolerance, and enjoy the benefits again. Nonetheless, this method is not ideal for patients who need regular pain control.

Try a Different Method

Factors such as body weight, height, time of the day, and method of consumption can affect CBD’s effectiveness. So, you should experiment with different approaches to know what is best for you.

 

 

Conclusion

No one can argue against the efficacy and effectiveness of CBD against various diseases such as Lyme disease and inflammation. However, some people are surprised that they are not able to experience these significant effects. For some people, it was all right and excellent until something went wrong, and the effects stopped. You need to check for CBD tolerance by leveraging the tips above. Note that you should speak to your doctor before you start using any medication. CBD oil is not a cure for every ailment in the world. Besides, you should be conversant with CBD regulations in your state to avoid running afoul of the law.

CBD Cluster Headaches

https://www.royalqueenseeds.com/blog-does-taking-cbd-too-often-cause-tolerance-n1089

References

Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling Accuracy of Cannabidiol Extracts Sold Online. JAMA. 2017;318(17):1708–1709. DOI:10.1001/jama.2017.11909

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D’Souza, D.C., et al., “Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis”, Biol Psychiatry Cogn Neurosci Neuroimaging, 2016, Volume 1, pg. 60-67.

Hayakawa, K. et al., “Repeated Treatment with Cannabidiol but not Delta9-Tetrahydrocannabinol Has a Neuroprotective Effect Without the Development of Tolerance”, Neuropharmacology, 2007, Volume 52, pg. 1079-1087.

Hayakawa, K., et al., “Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke.” Pharmaceuticals (Basel), 2010, Volume 3, pg. 2197-2212.

Pietrzykowski, A.Z., Treistman, S.N., “The Molecular Basis of Tolerance,” Alcohol Res Health, 2008, Volume 31, pg. 298-309.

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